CD274 and neoplasm: According to the results reported herein, the checkpoint inhibitors targeting PD-1 (nivolumab and pembrolizumab) and its ligand PD-L1 (MPDL3280A) provide a significant differential effect in terms of activity according to PD-L1 expression on tumor cells status, which translates into a higher ORR for PD-L1 positive advanced tumors in comparison to PD-L1 negative tumors, with an overall absolute difference of 14.2% (Fig 2).