The results obtained in 3T3-L1 preadipocytes after knockdown or overexpression of Agpat2 suggested that Agpat2 regulates adipogenesis through the modulation of the lipoma and by altering the normal activation of phosphatidylinositol 3-kinase (PI3K)/Akt and PPARγ pathways in the early stages of adipogenesis [32]. The gene discussed is PPARG; the disease is lipoma.