The observed in silico correlation between MURC/cavin-4 and Cav-3 was found to occur also in vivo and in vitro; indeed, immunohistochemical analysis of tumor samples detected MURC/cavin-4 staining frequently in Cav-3 expressing cells, whereas a robust and concurrent expression of both MURC/cavin-4 and Cav-3 was observed in human RMS lines and mouse primary tumor cultures only during differentiation. The gene discussed is CAVIN4; the disease is neoplasm.