In the case of collective migration, tumor cells form protrusions (pseudopodia)at the leading edge, use integrins to form focal contacts with the actincytoskeleton, and perform proteolytic degradation of the extracellular matrix,creating a space for invasion of the tumor tissue and extensively involving theactin-myosin contractile apparatus in the process to ensure successfulmigration [15, 20]. This evidence concerns the gene MYH14 and neoplasm.