In the pediatric CD microarray data analysis, the NF-κB binding sequence was over-presented in the inflammatory-related genes, such as CCL2, CXCL10, CXCL2, CXCL3, CXCL6, CXCL9, and in other up-regulated genes in the pediatric CD-inflamed colon tissue. This evidence concerns the gene CXCL2 and Cowden disease.