Consistent with these findings and in agreement with the increased expression of Cd36, hepatic Pparγ2 expression was up-regulated more than 2-fold in CBA, but not B6, mice on 3w SRD (compare Fig. 5, A and E), suggesting that hyperinsulinemia enhanced hepatic Pparγ2 expression in 3w SRD CBA mice. Here, PPARG is linked to hyperinsulinism.