To investigate a potential correlation between hyperinsulinemia and development of hepatosteatosis, we established an in vivo model for early onset hyperinsulinemia by exposing CBA/J (CBA), i.e. high insulin secreting, and C57BL6/J (B6), i.e. low insulin secreting, mice to a standard diet (CD) or standard diet plus 32% sucrose in the drinking water (sucrose-rich diet (SRD)) during a 3w period. This evidence concerns the gene INS and Hyperinsulinemia.