Thus, 3w of SRD not only provoked hyperinsulinemia and hepatosteatosis in CBA mice but also resulted in development of hepatic insulin resistance, as illustrated by the reduced in vivo response to exogenous insulin during an ITT, increased HOMA-IR, reduced insulin-stimulated hepatic AKT phosphorylation, and increased hepatic PKCε membrane translocation. This evidence concerns the gene INS and hyperinsulinism.