Pparγ, and in particular Pparγ2, overexpression promotes hepatic fat accumulation (21, –, 24) in an Srebp-1c independent way (25), whereas a liver-specific deletion of Pparγ attenuates hepatic steatosis, highlighting the important role for Pparγ in fatty liver development (26, –, 28). Here, PPARG is linked to fatty liver disease.