Hoeller et al. (2010) reported 50 % CD30-positive tumor cells in EBV-infected DLBCL in comparison with 4 % CD30-positive cells in EBV-negative cases and Oyama et al. (2007) showed 75 and 13 % of CD30-positive cells in EBV-positive and negative cases, respectively (P < 10−5). The gene discussed is TNFRSF8; the disease is diffuse large B-cell lymphoma.