Given the known role of CXCR4 as an inducer of migration and metastasis in PCa [28], and based on our results that GLIPR1-ΔTM inhibited the docetaxel-induced ERK1/2-c-Myc-CXCR4 signaling, we evaluated the hypothesis that the combination of GLIPR1-ΔΤΜ and docetaxel can inhibit migration of VCaP and PC-3 cells more than docetaxel alone. Here, CXCR4 is linked to posterior cortical atrophy.