In the current study, we report that GLIPR1-ΔΤΜ increases the sensitivity of PCa cells to docetaxel in a synergistic way through additive induction of JNK-mediated apoptosis in VCaP and PC-3 cells and concurrent inhibition of ERK1/2-c-Myc-CXCR4-mediated development of resistance. The gene discussed is MAPK8; the disease is posterior cortical atrophy.