Malignant melanoma is comprised of molecular subsets characterized by constitutively activating “driver” mutations in the serine-threonine kinase BRAF (codon V600), the GTPase NRAS (G12, G13, and Q61), the receptor tyrosine kinase KIT (W557, V559, L576, K642, and D816), and the Gα GTPases GNAQ (Q209) and GNA11 (Q209) [1–5]. The gene discussed is NRAS; the disease is melanoma.