Transcriptionally inactive MMP-14 gene promoter is characterized by deposition of H3K27me3 and hypermethylation of CpG islands [32], while low levels of H3K27me3 and under-methylation are observed at the MMP-14 promoter region in invasive and migratory cancer cells [32], suggesting that histone modification and DNA methylation are crucial factors impacting the transcriptional efficiency of MMP-14 promoter. Here, MMP14 is linked to cancer.