Instead, stable transfection of miR-337-3p precursor into NB cells resulted in increased binding of epigenetic markers enhancer of zeste homolog 2 (EZH2), histone H3 lysine 27 trimethylation (H3K27me3), and histone H3 lysine 9 dimethylation (H3K9me2), and decreased binding of RNA polymerase II (RNA Pol II) on MMP-14 promoter (Figure 4D), which was abolished by knockdown of AGO2 (Figure 4D). This evidence concerns the gene EZH2 and neuroblastoma.