BRAF and colorectal carcinoma: Our data suggest that i) BRAF antiapoptotic activity involves inhibition of the MTP opening and is TRAP1-dependent, ii) TRAP1 and BRAF interact, with BRAF signaling activation correlated with TRAP1 serine phosphorylation, iii) TRAP1 serine phosphorylation likely favors its antiapoptotic activity and iv) BRAF-addicted CRC cell lines are highly sensitive to both BRAF and TRAP1 targeting.