The relevance of TRAP1 serine phosphorylation for antiapoptotic activity was further evaluated in BRAF-V600E IRI-resistant HT29 cells, a tumor cell line characterized by higher TRAP1 levels compared to its drug-sensitive counterpart (Figure 6A) [14] and, thus, suitable for the study of phosphorylation levels of endogenous TRAP1 and the relevance of TRAP1 serine-phosphorylation for antiapoptotic activity. The gene discussed is BRAF; the disease is neoplasm.