To this aim, drug-induced apoptosis was evaluated in shTRAP1 CRC HCT116 (Figure 3C and Supplementary Figure 1A) and breast carcinoma (BC) MCF7 (Supplementary Figure 1B–1C) cells upon transfection of either BRAF-wt or BRAF-V600E constructs. The gene discussed is BRAF; the disease is breast cancer.