Together with the evidence that Apoe−/−Ltbrfl/flTagln-cre or Ltbrfl/flTagln-cre mice lacked changes of SLO structure and cellularity when compared to SLOs of Apoe−/−Ltbr−/− or Ltbr−/− mice but developed major alterations of ATLOs indicate that TLOs in other peripheral inflammatory and autoimmune diseases could also be targeted. Here, APOE is linked to autoimmune disease.