We also observed a parallel reduction in ATP-coupled and maximal respiration, as well as maximal glycolytic rate of activated cells, when comparing CD46-deficient CD4+ T cells to those from HDs (Figure 1D, patient CD46-2; Figure S1F, summary for all three patients; and Figure S1G for HD T cells after CD46-specific siRNA treatment). Here, CD46 is linked to Huntington disease.