For example, Notch regulates OXPHOS and glycolysis in cancer cells, pre-T cells, and memory cells (Ciofani and Zúñiga-Pflücker, 2005; Landor et al., 2011; Maekawa et al., 2015), and we have previously shown that interaction of CD46 and the Notch-family member Jagged1 regulates Th1 cell activation (Le Friec et al., 2012). Here, CD46 is linked to cancer.