SFN and hepatocellular carcinoma: Several studies have indicated that 14-3-3β, 14-3-3ε, 14-3-3γ, 14-3-3σ (also known as stratifin) and 14-3-3ζ isoforms are overexpressed in hepatocellular carcinoma (HCC) [15,16,17,18,19,20,21].