In addition to elevated pre-treatment KL-6 levels (>500.0 U/mL), significant independent factors of high grade RP noted in the Yamashita experience included elevated levels of SP-D (>110.0 ng/mL) and presence of an interstitial pneumonitis (IP) shadow on pre-treatment CT. The gene discussed is SFTPD; the disease is Interstitial pneumonitis.