While some case-control studies have identified associations between AGER SNPs and myocardial infarction and stroke [31] and prevalent coronary heart disease based on angiographic evidence of stenosis >50% [32], two recent meta-analyses including over 25 case-control studies (maximum N for single SNP = 7,111) [29] did not find a consistent association between AGER polymorphisms and coronary heart disease (odds ratios from meta-analyses ranged from 0.97 to 1.16 with P >0.05) [29, 30]. Here, AGER is linked to stroke disorder.