Interestingly, N-(1,3-benzodioxole-5-ylmethyl)-2,6-dichlorobenzamide (Alda-1), an aldehyde dehydrogenase 2 (ALDH2) agonist that increases the activity of mitochondrial ALDH2, inhibits myocardial damage caused by 4-HNE after ischemia [12, 14]. This evidence concerns the gene ALDH2 and ischemia.