Patients with lethal NHL had a recent diagnosis of HIV infection (median duration of HIV infection: 4 years) and were highly immunosuppressed with CD4 cell count in the same magnitude than in the previous national surveys (median: 75 CD4/mm3 in 2010 vs 76 CD4/mm3 in 2005 and 86 CD4/mm3 in 2000), with a higher proportion of patients with HIV RNA <500 copies/ml (58% in 2010 vs 48% in 2005). This evidence concerns the gene CD4 and HIV infectious disease.