These 11 genes were CDKN2B, HNF1A, HNF4A, IRS1, ITGB6, KCNJ11, LEP, PPARD, PPARG, SND1, and TCF7L2. Among them, KCNJ11, PPARG, and TCF7L2 have the strongest genetic association among genes that appear in the T2D GWAS studies based on a comprehensive review [59]. This evidence concerns the gene IRS1 and type 2 diabetes mellitus.