In summary, this study has the following major results: 1) we developed a computational framework for building drug-specific signaling pathway networks; 2) we generated a metformin-specific signaling pathway network that is significantly enriched with genes associated with T2D, cancer, or metformin-associated cancer survival, and 3) we pinpointed the MYC-centered pathway that may play important roles in metformin action. Here, MYC is linked to type 2 diabetes mellitus.