SerpinB2, also known as plasminogen activator inhibitor type 2 (PAI-2), is expressed by numerous cell types either constitutively (e.g. keratinocytes, peritoneal macrophages, syncytial trophoblasts) or inducibly following inflammation, infection or injury (e.g. monocytes/macrophages, fibroblasts, endothelial cells) [1,2]. This evidence concerns the gene SERPINB2 and infection.