However, some claudins may instead promote cell death, exemplified by the increased chemosensitivity to cisplatin through the claudin-7-mediated up regulation of caspase pathway in human NCI-H522 lung cancer cells [32] and stimulated anchorage-independent growth promoted by silencing of claudin-6 in breast carcinoma cells [33]. The gene discussed is CLDN6; the disease is lung carcinoma.