Claudin-1 expression conferred resistance to anoikis in colon cancer cells in a Src-dependent manner [29], reduced apoposis of nasopharyngeal carcinoma cells [27] and was also found to protect MCF-7 cells from TNF-α- and tamoxifen-induced death [30, 31]. This evidence concerns the gene CLDN1 and malignant colon neoplasm.