Using microRNA and mRNA profiling and validation we found an over-expression of miR-34c-5p and of a set of three genes (CD9, DHRS3 and PTPN7) in the monocytes of Ecuadorian T2D patients suggesting an altered adhesion, differentiation potential and shape change potential of the circulating monocytes. This evidence concerns the gene PTPN7 and type 2 diabetes mellitus.