The present study showed that RLTS was effective on attenuating CCl4-induced liver fibrosis in rats through modulating inflammatory process and oxidative stress, regulating TGF-β/Smad, FAK-PI3K-Akt-p70S6K and MAPK signaling pathways to restrain HSCs activation and decrease ECM production. Here, TGFB1 is linked to Hepatic fibrosis.