Its name derives from the fact that it is separately also the peptidase involved in cleavage of the β-amyloid precursor protein or β-APP, and in this role, mutations in Presenilin1 and Presenilin 2 in humans have been linked to familial early onset Alzheimer's disease as researched in PANTHER database database (Mi et al., 2005). Here, PSEN2 is linked to Alzheimer disease.