Notably, several reports revealed that some populations of TB patients display polymorphisms in genes linked to the autophagy pathway, namely, IRGM, IFNγ, IFNγ receptor, TLR8, Vitamin D3 (VDR), and ATP receptor (P2X7R), suggesting that some individuals might be more prone to develop TB due to a defective autophagic response (Songane et al., 2012). Here, IRGM is linked to tuberculosis.