Though the knockout of H19 is not lethal in mice [110], its over-expression, either due to loss of imprinting (LOI) at H19 locus or due to the loss of tumor suppressor gene p53 [111], or under the influence of the oncogene, Myc [112], leads to the activation of genes involved in angiogenesis, cell survival and proliferation [113, 114], triggering several malignancies like liver [115, 116], breast [117], colorectal [118], esophageal [119], lung [120], pancreatic [121], gastric [122], bladder [123] and cervical [124] carcinomas suggesting an oncogenic function for this RNA. Here, H19 is linked to carcinoma.