HOTAIR is known to repress several tumor and metastasis suppressor genes like HOXD10 (Homeobox D10), PGR (Progesterone Receptor), PCDH10 (Protocadherin10), PCDHB5 (Protocadherin Beta 5), JAM2 (Junctional Adhesion Molecule 2), etc. [160–162] and therefore its up-regulation leads to a variety of malignancies like primary/ metastatic breast cancers [161, 163–165], hepatocellular [166–168], colorectal [162], gastrointestinal [169, 170] and non-small cell lung carcinomas [171]. The gene discussed is PGR; the disease is neoplasm.