TNF and neoplasm: Other promising agents include TLR7/8 agonists (e.g., imiquimod, resiquimod), which stimulate TNF-α/IFN-α production by tumor-resident plasmacytoid DCs (126), and TLR9 agonists (e.g., CpG-containing oligodeoxynucleotides), which augment DC activation, enhance TME infiltration by effector T-cells, and inhibit Treg/MDSCs in preclinical models (127).