Moreover, when TILs were characterized, CD8+ T cells were enriched as in controls, but they displayed a more activated and differentiated phenotype given by elevated expression of the transcription factors T-bet and Eomes, higher IFN-γ secretion, and granzyme B production, demonstrating that IL-33 controls CD8+ T cells differentiation and effector function, which can be manipulated for anti-tumor therapy (36). This evidence concerns the gene IL33 and neoplasm.