RAD51 and familial congenital mirror movements: More recently, we found that the SMA activation pattern and connectivity are abnormal during both unimanual and bimanual movements in Rad51-mutated CMM patients (Figure 1C; Gallea et al., 2013) This suggested that cortical activation and connectivity might be modified in CMM patients during movement preparation, resulting in inappropriate delivery of the motor program from the SMA to both primary motor cortices.