SNCA and Parkinson disease: Supporting this, toxin-induced dopaminergic neurodegeneration, classically employed as PD model, is dependent on alpha-synuclein abundance: Knock-out mice were resistant to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrine (MPTP)-induced toxicity of dopaminergic cells (Dauer et al., 2002).