Thus, idiopathic and familial AD might differ in etiology, however, idiopathic AD-brains display enhanced neuronal ROCK2-protein levels (Herskowitz et al., 2013) as well as an altered subcellular distribution of its upstream effector RhoA which is a characteristic in common with genetic AD-mouse models (Huesa et al., 2010). Here, ROCK2 is linked to Alzheimer disease.