To increase the signal to noise ratio in our experiments, we utilized SW620 colon cancer cells (herein referred to as “SW620inv”) that were selected for high invasive potential and low E-cadherin expression by passage through Matrigel, and all the selected clones shown E-cadherin restoration by Trichostatin A (TSA), a known histone deacetylase (HDAC) inhibitor, as parental SW620 (Supplementary Figure 1). The gene discussed is CDH1; the disease is malignant colon neoplasm.