Vesicles as non-invasive placental biopsies in pregnancy were described by I. Sargent (University of Oxford, UK) and studies in preeclampsia of vesicles binding antibodies to cholera toxin recognising GM1 gangliosides or Annexin V recognising phosphatidyl serine showed elevations of preeclampsia related proteins and might represent biomarkers for preeclampsia (as discussed by T.S. Sim (Institute of Medical Biology, Singapore)). Here, ANXA5 is linked to preeclampsia.