We previously reported that prominin-1 had a pro-metastatic role in melanoma cells (Rappa et al., Stem Cells 26, 3008, 2008) and that microvesicles released from metastatic melanoma cells expressed high levels of prominin-1 (Rappa et al., Exp Cell Res 319, 810, 2013). Here, PROM1 is linked to melanoma.