To investigate whether uPAR/CXCR4 expression in AML cell lines could be regulated by endogenously expressed selected miRs, LNAs specific for miR-146a, miR-335 and miR-622 or a control LNA were transfected in KG1 cells, which showed higher miR levels and lower uPAR/CXCR4 expression as compared to pro-monocytic cells (Fig.3). This evidence concerns the gene CXCR4 and acute myeloid leukemia.