Both uPAR and CXCR4 are differentially expressed in AML, with lower expression in undifferentiated (M0), myeloid (M1/2) and erythroid (M6) AML, and higher expression in promyelocytic (M3) and myelomonocytic (M4/5) AML 22,25. Here, CXCR4 is linked to acute myeloid leukemia.