Furthermore, overexpression of all selected miRs lowered uPAR/CXCR4 expression in THP-1 cells and, viceversa, the specific inhibition of all three miRs increased uPAR/CXCR4 expression in KG1 cells, confirming a functional role of selected miRs in leukaemia cell lines. Here, CXCR4 is linked to leukemia.