Etienne Moussay (CRP-Santé, Luxemburg) and Noah Hornick (Oregon Health & Science University, USA) highlighted the importance of leukaemia-derived EVs (a cooperating action of exosomes and microvesicles or exosomes alone) in the regulation of the BM microenvironment in chronic lymphocytic leukaemia (CLL) and acute myeloid leukaemia (AML) models, respectively. The gene discussed is CRP; the disease is B-cell chronic lymphocytic leukemia.