In order to understand how tumor cell exosomes affect their environment and how oncogenic mutations alter the output of tumor-derived exosomes, we have performed LC-MS-MS proteomic analysis of exosomes from colon cancer cells DLD-1 (with one mutant and one wild-type KRAS allele) and isogenically matched DKO-1 (with only a mutant KRAS allele) or DKS-8 cells (with only a wild-type KRAS allele). Here, KRAS is linked to neoplasm.