Studies supported by this biorepository include EGFR and EGFRvIII detection in exosomal RNA (exoRNA) from serum, BEAMing PCR for CSF-exosome-derived mutant IDH1, examinations of de novo vs. secondary GBM, detection of novel oncogenes using microarray profiles, BRAF V600E in serum-derived exoRNA, as well as the exoRNA contribution of circulating lymphocytes and protein detection using a novel NMR technology. This evidence concerns the gene EGFR and glioblastoma.