In our previous work, we tested three new drugs, two serine/threonine-protein kinase B-Raf (BRAF) inhibitors (RAF265 and SB590885) and a PI3K inhibitor (ZSTK474), on differentiated thyroid cancer cell lines carrying the BRAF V600E mutation, discovering that the combination of drugs profoundly affected proliferation via the mitogen-activated protein kinases (MAPK) and PI3K/Akt signalling pathways 14. Here, BRAF is linked to thyroid cancer.