The patient's total serum cholesterol levels before transplantation were 800–1,000 mg dl−1; she had already developed cardiovascular disease despite lipid-lowering drug therapy (Supplementary Table 1), and genetic testing revealed compound heterozygosity (Cys134Tyr and Cys368Tyr) in the LDLR gene (Supplementary Table 2) and an apolipoprotein E (APOE) genotype E3/E3. This evidence concerns the gene APOE and cardiovascular disorder.