We compared numbers of neurons containing calcium‐binding proteins parvalbumin (PV), calbindin (CB), and calretinin (CR) and densities of respective fibers in lateral temporal lobe surgical specimens of 17 patients with FCD with 19 patients who underwent anterior temporal lobe resection due to nonlesional temporal lobe epilepsy (non‐FCD) as well as with 7 postmortem controls. This evidence concerns the gene PVALB and temporal lobe epilepsy.