As shown in Fig. 5, the relative mRNA levels of c-fos and TRPV1 in the ipsilateral spinal cord and of ASIC3 in the ipsilateral DRG in the cancer, cancer with NS, cancer with ZOL and cancer with TA groups were significantly increased, compared with the naive and sham groups (P<0.05). This evidence concerns the gene ASIC3 and cancer.