The analysis identified 50 significant autoantigens, all of which had higher reactivity in pSLE patient serum than in healthy control serum (q-value <0.001, fold change >2), including known serologic markers for SLE (e.g. Ro, La, Smith, dsDNA, histones, RNP). This evidence concerns the gene RNPC3 and systemic lupus erythematosus.