Following an 8-week high-fat diet and intraperitoneal injection of STZ, the levels of FBG, TC and LDL-C were significantly higher in the ApoE−/− mice in the HF group, compared with those in the CON group (P<0.05); no significant differences were observed in body weight, TG, FFA, INS and GHb between these two groups (P>0.05; Fig. 5B). Here, APOE is linked to hydrops fetalis.