Significantly elevated levels of GAD65 were observed in the samples from SPS patients (median, 1.129 ng/ml; range 13.2 pg/ml-1.513 ng/ml) compared to those from the control group (median, 43 pg/ml; range 11.3 pg/ml-1.036 ng/ml, p = 0.01) (Fig. 1C. The gene discussed is GAD2; the disease is stiff-person syndrome.