This observation supports a model in which P38 is not important for CaD phosphorylation in PCa cells and LPXN regulates the phosphorylation of CaD via ERK; this phosphorylation affects the binding of CaD to actin and thereby regulates actin-cytoskeletal dynamics (Figure 8B) and the migratory ability of PCa cells. Here, CAD is linked to posterior cortical atrophy.