It is a potentially life threatening condition, both for the mother and the fetus.[1] In normal pregnancy, there is a 2- to 4-fold increase in serum triglyceride (TG) levels due to increased hepatic synthesis of very-low-density lipoproteins (VLDL) in response to elevated estrogen levels and reduced lipoprotein lipase (LPL) activity.[2] However, this moderate physiological hypertriglyceridemia (HTG) is seldom associated with any adverse clinical consequences. The gene discussed is LPL; the disease is hypertriglyceridemia.