CCND2 and neoplasm: In addition to CD44 activation, we examined the expression status of multiple Wnt downstream targets from RNA-seq and found that the expression of other Wnt targets was collectively orchestrated into two groups: (i) Significantly up-regulated genes from one group were associated with stem cell self-renewal (Myc) [22], Wnt signaling receptor that can down-regulate tumor suppressive APC gene (FZD7) [23], stemness maintenance (CCND2) [24], and AP-1 family transcription factors associated with tumor growth (Fosl1 and Jun) [25].