Each of these SNP sets included rs6857 near APOE, which is strongly associated with AD risk (OR: 3.2; p = 2.5 × 10−575) [12] (S4 and S5 Figs) and which was a very clear outlier when we compared effect sizes on lipids against effect sizes on AD (S6–S11 Figs). Here, APOE is linked to Alzheimer disease.