For example, while we saw no evidence to support causal roles for BMI, fasting glucose, or insulin resistance in AD (all p > 0.1), confidence intervals allow for an almost 20% higher AD risk per 1-SD difference in BMI, a 30% higher AD risk per 1-SD difference in fasting glucose, and an almost 100% higher AD risk per 1-SD difference in log-fasting insulin (Table 1). This evidence concerns the gene INS and Insulin resistance.