Results indicated that DNMT1 expression was significantly higher in later stage T2D mice (KK versus yKK at 6, 16, and 42 weeks were 0.86, 0.95, and 2.44 respectively, P < 0.05, Fig. 3D), but that of DNMT3A, DNMT3B, and DNMT3L was unaffected. Here, DNMT1 is linked to type 2 diabetes mellitus.