Combined therapy eradicated 60% of established Neuro2a tumors in the wild-type model (Fig 3B) and 90% in AgN2a (aggressive non-immunogenic) model (Figs 3C, 4A and 4B), whereas, CTLA-4 blockade alone resulted in 40% tumor regression in the Neuro2a model and had no effect on tumor growth in the AgN2a model (Fig 3B and 3C). This evidence concerns the gene CTLA4 and neoplasm.