In patients with type 1 diabetes the insulin infusion rate begins at roughly 0.5–1 U/hour (mix 100 U short-acting insulin in 100 mL normal saline; i.e., 1 U = 1 mL), whereas infusion rates are typically increased in type 2 diabetics to approximately 2-3 U/hour or higher [20]. This evidence concerns the gene INS and type 2 diabetes mellitus.